Search scope:
排序: Display mode:
Neutralizing monoclonal antibodies present new prospects to treat SARS-CoV-2 infections
Rongtao Lai, Tianhui Zhou, Xiaogang Xiang, Jie Lu, Haiguang Xin, Qing Xie
Frontiers of Medicine 2021, Volume 15, Issue 4, Pages 644-648 doi: 10.1007/s11684-021-0847-4
Keywords: neutralizing antibody antibody cocktail SARS-CoV-2 COVID-19 therapeutic strategy
Passive antibody therapy in emerging infectious diseases
Frontiers of Medicine doi: 10.1007/s11684-023-1021-y
Keywords: SARS-CoV-2 COVID-19 convalescent plasma hyperimmunoglobulin neutralizing monoclonal antibodies
Broadly neutralizing antibodies and vaccine design against HIV-1 infection
Qian Wang, Linqi Zhang
Frontiers of Medicine 2020, Volume 14, Issue 1, Pages 30-42 doi: 10.1007/s11684-019-0721-9
Keywords: HIV-1 broadly neutralizing antibodies Env conformational states vaccine design SOSIP
Human monoclonal antibodies as candidate therapeutics against emerging viruses
Yujia Jin, Cheng Lei, Dan Hu, Dimiter S. Dimitrov, Tianlei Ying
Frontiers of Medicine 2017, Volume 11, Issue 4, Pages 462-470 doi: 10.1007/s11684-017-0596-6
Keywords: human monoclonal antibodies emerging infectious diseases SARS-CoV MERS-CoV Ebola virus
Durability of neutralizing antibodies and T-cell response post SARS-CoV-2 infection
Yun Tan, Feng Liu, Xiaoguang Xu, Yun Ling, Weijin Huang, Mingquan Guo, Ziyu Fu, Dongguo Liang, Miao Xu, Hongzhou Lu, Saijuan Chen
Frontiers of Medicine 2020, Volume 14, Issue 6, Pages 746-751 doi: 10.1007/s11684-020-0822-5
Keywords: SARS-CoV-2 neutralizing antibodies T-cell response
Yulu Wang, Dan Hu, Yanling Wu, Tianlei Ying
Frontiers of Medicine 2020, Volume 14, Issue 2, Pages 149-159 doi: 10.1007/s11684-020-0764-y
Keywords: influenza virus neutralizing antibody hemagglutinin globular head region trimeric interface
Xi Lu,Guoqing Li,Jing Pang,Xinyi Yang,Colette Cywes-Bentley,Xuefu You,Gerald B. Pier,
Engineering doi: 10.1016/j.eng.2023.09.012
Keywords: Poly- N -acetylglucosamine Conjugate vaccine Monoclonal antibody
Huan HE, Bo TANG, Cheng SUN, Shaogui YANG, Weijuan ZHENG, Zichun HUA
Frontiers of Environmental Science & Engineering 2011, Volume 5, Issue 3, Pages 409-416 doi: 10.1007/s11783-011-0349-8
Keywords: cadmium hapten monoclonal antibody enzyme-linked immunosorbent assay (ELISA)
Synthesis of haptens and production of antibodies to bisphenol A
Xiya ZHANG, Xiaoyun DONG, Sijun ZHAO, Yuebin KE, Kai WEN, Suxia ZHANG, Zhanhui WANG, Jianzhong SHEN
Frontiers of Agricultural Science and Engineering 2017, Volume 4, Issue 3, Pages 366-372 doi: 10.15302/J-FASE-2017132
Keywords: bisphenol A cross-reactivity hapten indirect competitive ELISA polyclonal antibody
Growth suppression of colorectal cancer expressing S492R EGFR by monoclonal antibody CH12
Qiongna Dong, Bizhi Shi, Min Zhou, Huiping Gao, Xiaoying Luo, Zonghai Li, Hua Jiang
Frontiers of Medicine 2019, Volume 13, Issue 1, Pages 83-93 doi: 10.1007/s11684-019-0682-z
Keywords: S492R EGFR ectodomain mutation colorectal cancer mAb CH12 immunnotherapy
Mengmeng ZHAO,Juanjuan QIAN,Jiexiong XIE,Tiantian CUI,Songling FENG,Guoqiang WANG,Ruining WANG,Guihong ZHANG
Frontiers of Agricultural Science and Engineering 2016, Volume 3, Issue 2, Pages 153-160 doi: 10.15302/J-FASE-2016097
Keywords: PRRSV Nsp9 expression antibody neutralize
From SARS to MERS: evidence and speculation
Hainv Gao,Hangping Yao,Shigui Yang,Lanjuan Li
Frontiers of Medicine 2016, Volume 10, Issue 4, Pages 377-382 doi: 10.1007/s11684-016-0466-7
The Middle East respiratory syndrome coronavirus (MERS-CoV) is a novel zoonotic pathogen. In 2012, the infectious outbreak caused by MERS-CoV in Saudi Arabia has spread to more than 1600 patients in 26 countries, resulting in over 600 deaths. Without a travel history, few clinical and radiological features can reliably differentiate MERS from SARS. But in real world, comparing with SARS, MERS presents more vaguely defined epidemiology, more severe symptoms, and higher case fatality rate. In this review, we summarize the recent findings in the field of MERS-CoV, especially its molecular virology, interspecies mechanisms, clinical features, antiviral therapies, and the further investigation into this disease. As a newly emerging virus, many questions are not fully answered, including the exact mode of transmission chain, geographical distribution, and animal origins. Furthermore, a new protocol needs to be launched to rapidly evaluate the effects of unproven antiviral drugs and vaccine to fasten the clinical application of new drugs.
Keywords: middle east respiratory syndrome animal origin cross-species transmission monoclonal antibody
The biopharmaceutical industry in China: history and future perspectives
Kai Gao, Junzhi Wang
Frontiers of Medicine 2012, Volume 6, Issue 2, Pages 101-111 doi: 10.1007/s11684-012-0191-9
Biopharmaceuticals reflect the rapid progress achieved in modern biomedical research. This area has also become one of the main criteria for assessing the development level of biotechnology for a particular country. Although it has been only three decades since the first biopharmaceutical, recombinant human insulin, was licensed by the US Food and Drug Administration, the biopharmaceutical industry has become the fastest growing, most dynamic and technology-intensive sector in the biomedical field. Since the licensing of recombinant human interferon α1b in 1989, the biopharmaceutical industry in China has gone through initial developments and gradually entered a period of rapid growth. This paper provides an overview of the status and development trends of biopharmaceuticals in China, and compares them with those observed in developed countries.
Keywords: biopharmaceuticals antibodies market trends diseases China national regulatory agency
Emerging immunological strategies: recent advances and future directions
Frontiers of Medicine 2021, Volume 15, Issue 6, Pages 805-828 doi: 10.1007/s11684-021-0886-x
Keywords: cancer immunotherapy bispecific antibodies small molecules chimeric antigen receptor T therapy cancer
Wenjing Zhang,Fei Gao,Donghe Lu,Na Sun,Xiaoxue Yin,Meili Jin,Yanhong Liu
Frontiers of Medicine 2016, Volume 10, Issue 1, Pages 76-84 doi: 10.1007/s11684-015-0426-7
Anti-β2 glycoprotein I (anti-β2GP I ) antibodies are importantHowever, the mechanism by which anti-β2GP I antibodies are involved in the pathogenesisIn this report, we investigated the role of anti-β2GP I antibodies in complexes with
Keywords: anti-β2GP I /β2GP I complex platelet GP I bα apoER2' thrombosis
Title Author Date Type Operation
Neutralizing monoclonal antibodies present new prospects to treat SARS-CoV-2 infections
Rongtao Lai, Tianhui Zhou, Xiaogang Xiang, Jie Lu, Haiguang Xin, Qing Xie
Journal Article
Broadly neutralizing antibodies and vaccine design against HIV-1 infection
Qian Wang, Linqi Zhang
Journal Article
Human monoclonal antibodies as candidate therapeutics against emerging viruses
Yujia Jin, Cheng Lei, Dan Hu, Dimiter S. Dimitrov, Tianlei Ying
Journal Article
Durability of neutralizing antibodies and T-cell response post SARS-CoV-2 infection
Yun Tan, Feng Liu, Xiaoguang Xu, Yun Ling, Weijin Huang, Mingquan Guo, Ziyu Fu, Dongguo Liang, Miao Xu, Hongzhou Lu, Saijuan Chen
Journal Article
Recent advances in “universal” influenza virus antibodies: the rise of a hidden trimeric interface in
Yulu Wang, Dan Hu, Yanling Wu, Tianlei Ying
Journal Article
Antibodies Targeting a Conserved Surface Polysaccharide Are Protective Against a Wide Range of Microbial
Xi Lu,Guoqing Li,Jing Pang,Xinyi Yang,Colette Cywes-Bentley,Xuefu You,Gerald B. Pier,
Journal Article
Preparation of hapten-specific monoclonal antibody for cadmium and its ELISA application to aqueous samples
Huan HE, Bo TANG, Cheng SUN, Shaogui YANG, Weijuan ZHENG, Zichun HUA
Journal Article
Synthesis of haptens and production of antibodies to bisphenol A
Xiya ZHANG, Xiaoyun DONG, Sijun ZHAO, Yuebin KE, Kai WEN, Suxia ZHANG, Zhanhui WANG, Jianzhong SHEN
Journal Article
Growth suppression of colorectal cancer expressing S492R EGFR by monoclonal antibody CH12
Qiongna Dong, Bizhi Shi, Min Zhou, Huiping Gao, Xiaoying Luo, Zonghai Li, Hua Jiang
Journal Article
Characterization of polyclonal antibodies against nonstructural protein 9 from the porcine reproductive
Mengmeng ZHAO,Juanjuan QIAN,Jiexiong XIE,Tiantian CUI,Songling FENG,Guoqiang WANG,Ruining WANG,Guihong ZHANG
Journal Article
From SARS to MERS: evidence and speculation
Hainv Gao,Hangping Yao,Shigui Yang,Lanjuan Li
Journal Article
The biopharmaceutical industry in China: history and future perspectives
Kai Gao, Junzhi Wang
Journal Article